Document Details

Document Type : Article In Journal 
Document Title :
Giardia duodenalis pathogenicity on immunosuppressed animal model
إمراضية الجيارديا الاثني عشرية على نموذج حيواني مثبط مناعياً
 
Subject : Scientific Research 
Document Language : English 
Abstract : Giardiasis is the major water-borne diarrheal disease present worldwide caused by the common intestinal parasite, Giardia duodenalis. This work aims to investigate the effect of G. duodenalis infection pathogenicity in immunosuppressed animals through histopathological examination. A total of 45 BALB/c mice were divided into four groups; G1 (negative control), G2 (healthy animals exposed to Giardia); G3 (immunosuppressed animals exposed to Giardia), and G4 (non-exposed immunosuppressed animals). Our study revealed that G3 was the most affected group with an infection rate of 100%. The animals showed general weakness, soft stool, and high death rate with severe histopathological changes in the duodenum and mild degenerative changes in hepatic tissues. In G2, the maximal lesions in both duodenum and liver were on the 11th day. We spotted damage in the villi, edema in the central core, and submucosa, in addition to increased cellular infiltration with inflammation in lamina propria. The presence of the parasites within the villi and the lumen was clear. Most of the hepatocytes revealed hydropic and fatty changes, also dilated congested central veins and edema were observed. G3 changes were more intense than G2 with massive Giardia trophozoites between the intestinal villi, lumen, and extensive fatty liver degeneration. Immune suppression plays a significant role in the severity of injury with the Giardia parasites in duodenum and liver cells. 
ISSN : 2521-9855 
Journal Name : Tropical Biomedicine 
Volume : 37 
Issue Number : 4 
Publishing Year : 1441 AH
2020 AD 
Article Type : Article 
Added Date : Tuesday, April 5, 2022 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ماجد حمدي واكدWakid, Majed H.InvestigatorDoctoratemwakid@kau.edu.sa
فوزية هـ طولةTOULAH, FAWZIA H.ResearcherDoctorate 
هيفاء أ محجوبMahjoub, Haifa AResearcherMaster 
مسلمة ن السلميAlsulami, Muslimah NResearcherDoctorate 
وفاء م هيكلHikal, ًWafa MResearcherDoctorate 

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