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Document Type |
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Article In Journal |
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Document Title |
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In Vitro Antihelminthic Activity of Ethanol Zingiber Officinale Extract on Fasciola gigantica in Comparison to Triclabendazole نشاط مضاد للديدان في المختبر لمستخلص الإيثانول Zingiber Officinale على Fasciola gigantica بالمقارنة مع Triclabendazole |
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Subject |
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Scientific Research |
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Document Language |
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English |
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Abstract |
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Fascioliosis, caused by Fasciola hepatica and Fasciola gigantica, is considered one of the most important helminthes diseases among both humans and animals. The use of Triclabendazole (TCBZ) as the only antihelminthic drug against fascioliosis faced recent problems being of many side effects and documented resistance against it has been reported. Given the widespread use of ginger (Zingiber officinale) in many traditional medicines and the various metabolic properties reported of it, this study aims to investigate the in vitro antihelminthic activity of Zingiber officinale ethanol extracts on Fasciola gigantica and in comparison to TCBZ. Fifty-four live Adult Fasciola gigantica worms were divided into nine groups of six each including, positive control (G1), negative control (G2), 20 μg/ml TCBZ-SO (G3), ginger extract of 5, 25 or 50 mg/ml (G4, G5 and G6, respectively) and combined TCBZ-SO with ginger extract of 5, 25 or 50 mg/ml (G7, G8 and G9, respectively). The worm motility scores, survival index and histological examination were utilized to further analyze the effect of treatments on the worms' morphology. Results indicated a marked decrease in worms' motility treated with ginger extracts compared to TCBZ-SO group. The decrease observed was positively correlated to both time and concentration. Histological examination showed that a higher concentration of ginger extract alone or in combination with TCBZ-SO caused severe tegumental alterations, more than those observed in TCBZ-SO treatment alone. In conclusion, the results strongly confirm the plausible development of ginger-based antihelminthic drug against Fasciola gigantica infection. |
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ISSN |
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1110-5356 |
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Journal Name |
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Journal of the Egyptian Society of Parasitology |
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Volume |
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29 |
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Issue Number |
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3 |
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Publishing Year |
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1441 AH
2019 AD |
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Article Type |
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Article |
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Added Date |
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Thursday, March 31, 2022 |
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Researchers
| فوزية هـ طولة | TOULAH, FAWZIA H. | Investigator | Doctorate | |
| صافيناز ج عاشور | ASHOOR, SAFINAZ J. | Researcher | Doctorate | |
| ماجد ح واكد | Wakid, Majed H | Researcher | Doctorate | mwakid@kau.edu.sa |
| منى ر الشاذلي | ALSHATHLY, MONA R. | Researcher | Doctorate | |
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