Document Details Document Type : Article In Journal  Document Title : An integrated catalog of reference genes in the human gut microbiome An integrated catalog of reference genes in the human gut microbiome   Document Language : English  Abstract : Many analyses of the human gut microbiome depend on a catalog of reference genes. Existing catalogs for the human gut microbiome are based on samples from single cohorts or on reference genomes or protein sequences, which limits coverage of global microbiome diversity. Here we combined 249 newly sequenced samples of the Metagenomics of the Human Intestinal Tract (MetaHit) project with 1,018 previously sequenced samples to create a cohort from three continents that is at least threefold larger than cohorts used for previous gene catalogs. From this we established the integrated gene catalog (IGC) comprising 9,879,896 genes. The catalog includes close-to-complete sets of genes for most gut microbes, which are also of considerably higher quality than in previous catalogs. Analyses of a group of samples from Chinese and Danish individuals using the catalog revealed country-specific gut microbial signatures. This expanded catalog should facilitate quantitative characterization of metagenomic, metatranscriptomic and metaproteomic data from the gut microbiome to understand its variation across populations in human health and disease.  ISSN : 1087-0156  Journal Name : NATURE BIOTECHNOLOGY  Volume : 32  Issue Number : 8  Publishing Year : 1435 AH 2014 AD  Article Type : Article  Added Date : Monday, August 14, 2017  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email Junhua Li Li, Junhua Researcher     Huijue Jia Jia, Huijue Researcher     Xianghang Cai Cai, Xianghang Researcher     Huanzi Zhong Zhong, Huanzi Researcher     Qiang Feng Feng, Qiang Researcher     Shinichi Sunagawa Sunagawa, Shinichi Researcher     Manimozhiyan Arumugam Arumugam, Manimozhiyan Researcher     Jens Kultima Kultima, Jens Researcher     Edi Prifti Prifti, Edi Researcher     Trine Nielsen Nielsen, Trine Researcher     Agnieszka Juncker Juncker, Agnieszka Researcher     Chaysavanh Manichanh Manichanh, Chaysavanh Researcher     Bing Chen Chen, Bing Researcher     Wenwei Zhang Zhang, Wenwei Researcher     Florence Levenez Levenez, Florence Researcher     Juan Wang Wang, Juan Researcher     Xun Xu Xu, Xun Researcher     Liang Xiao Xiao, Liang Researcher     Suisha Liang Liang, Suisha Researcher     Dongya Zhang Zhang, Dongya Researcher     Zhaoxi Zhang Zhang, Zhaoxi Researcher     Weineng Chen Chen, Weineng Researcher     Hailong Zhao Zhao, Hailong Researcher     Jumana (Al-Aama (Al-Aama, Jumana Researcher     Sherif Edris Edris, Sherif Researcher     Huanming Yang Yang, Huanming Researcher     Jian Wang Wang, Jian Researcher     Torben Hansen Hansen, Torben Researcher     Henrik Nielsen Nielsen, Henrik Researcher     Soren Brunak Brunak, Soren Researcher     Karsten Kristiansen Kristiansen, Karsten Researcher     Francisco Guarner Guarner, Francisco Researcher     Oluf Pedersen Pedersen, Oluf Researcher     Joel Dore Dore, Joel Researcher     S Ehrlich Ehrlich, S Researcher     Peer Bork Bork, Peer Researcher     Jun Wang Wang, Jun Researcher     Files File Name Type Description  42628.pdf pdf   Back To Researches Page