Document Details

Document Type : Article In Journal 
Document Title :
Synthesis and biological evaluation of new oxime-ether derivatives of steroid as anti-bacterial agents
Synthesis and biological evaluation of new oxime-ether derivatives of steroid as anti-bacterial agents
 
Subject : Chemistry 
Document Language : English 
Abstract : Various oxime-ether derivatives of cholesterol have been synthesized by the alkylation of the steroidal oxime with 1-(2-chloroethyl) pyrrolidine hydrogen chloride/chloroethylamine hydrochloride in the presence of sodium methoxide in dry methanol. The structures of these compounds were elucidated by IR 1H NMR, FAB mass spectroscopic methods and elemental analyses. The anti-bacterial activity was first tested in vitro by the disk diffusion method against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) of compounds were determined. The results showed that the chloro derivatives exhibited better anti-bacterial activity than the standard drug chloramphenicol. 
ISSN : 1319-6103 
Journal Name : Journal of Saudi Chemical Society 
Volume : 16 
Issue Number : 1 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Tuesday, February 28, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سلمان أحمد خانKhan, Salman AResearcherDoctoratesahmad_phd@yahoo.co.in
عبدالله محمد عسيريAsiri, Abdullah MohamedResearcherDoctorateaasiri2@kau.edu.sa
Kishwar SaleemSaleem, Kishwar ResearcherDoctorate 

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