Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Relationship between bone mineral density, lean body mass, vitamin-D status and parathyroid hormone in postmenopausal women: a prospective study: MSM Ardawi, MH Qari, AA Rouzi, R. Radady and A. Maimany الكثافة الكتلية العظمية وعلاقتها بالكتلة الجسدية اللينة والحالة التغذوية لفيتامين – د وهرمون الغدة جار درقية في النساء ما بعد انقطاع الطمث: دراسة تطلعية. |
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Subject |
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التغذية السريرية وأمراض الغدد الصماء |
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Document Language |
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English |
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Abstract |
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Title: Relationship between bone mineral density, lean body mass, vitamin-D status and parathyroid hormone in postmenopausal women: a prospective study: MSM Ardawi, MH Qari, AA Rouzi, R. Radady and A. Maimany
Objective: To assess the relationship between bone mineral density (BMD) and lean body mass, vitamin D and parathyroid hormone (PTH) in Saudi postmenopausal women.
Design: A prospective Study.
Setting: Tertiary Referral University Hospital.
Subjects and Methods: A total of 790 Saudi postmenopausal women living in the Jeddah area were studied. Bone mass and lean body mass were measured by a dual-energy X-ray absorptiometry. Plasma 25-OH-D3 and intact-PTH were measured together with biochemical bone turnover markers including [formation: serum osteocalcin (OC), bone alkaline phospatase (BAP), and absorption: C-telopeptide fragment of type 1collagen (sCTx), and cross-linked N-telopeptide type 1 collagen (sNTx) and serum calcium, phosphate and magnesium. The relationship between bone mass and lean body mass and other variables were examined using univariate analysis by means of Chi-square test and multivariable analysis using multiple logistic regression. ANOVA was used to examine the differences among women according to quartiles of 25-OH-D3 values.
Results: Serum 25-OH-D3 correlated with all skeletal sites in women studied except for the spine (r=0.18 – 0.32; P < 0.05) BMD at sites enriched in cortical bone were 0.3 – 0.8 SD lower in the women with the lowest vitamin-D quartile as compared with that in the highest quartile. After adjusting for intact-PTH, the magnitude of correlation between BMD and 25-OH-D3 remained significant. After controlling for lean body mass the magnitude of these correlations did not significantly change. After controlling for age and height, both lean body mass and intact-PTH contributed significantly to BMD variation at all skeletal sites examined. Adjusting for age, height, lean mass, PTH, 25-OH-D3 did not show any significant residual contribution to BMD variation.
Conclusions: Vitamin-D effects on BMD in postmenopausal women is largely mediated via variations of intact-PTH rather than that of lean body mass. |
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ISSN |
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2356 |
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Journal Name |
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مدونات التغذية وهشاشة العظام |
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Volume |
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1 |
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Issue Number |
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7 |
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Publishing Year |
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1430 AH
2009 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, August 1, 2010 |
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Researchers
| محمد صالح العرضاوي | Ardawi, Mohammed Saleh | Investigator | Doctorate | ardawims@yahoo.com |
| طلال محمد بخش | Bahksh, Talal Mohammed | Researcher | Doctorate | |
| محمد حسن قاري | Qari, Mohammed Hassan | Researcher | Doctorate | |
| عبد الرحيم علي روزي | Rozi, Abdulrahem Ali | Researcher | Doctorate | |
| رجاء محمد الردادي | Al Radadi, Rajaa Mohammed | Researcher | Doctorate | |
| عبد الرؤوف ميمني | Maimani, Abdulraoof | Researcher | Doctorate | |
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